The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model

This study aimed to evaluate the efficacy and safety of non focused ultrasound by applying 1 MHz nonfocused ultrasound at 3 W/cm2 to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. Our experiment demonstrated that the 1 MHz ultrasound at 3 W/cm2 is effective at releasing stored lipid from targeted fat cells as well as reducing subcutaneous fat thickness. The combination of an average fat reduction of 0.5mm from a single 30-minute session with persistent lasting effects makes low-intensity ultrasound a promising cosmetic treatment for body contouring. Furthermore, the comparatively low intensity, that is, 3W/cm2, makes it much safer than the HIFU in body contouring, especially with repetitive treatments.